Fine-Tuning Endothelial Notch: SIRT-ainly an Unexpected Mechanism
نویسندگان
چکیده
منابع مشابه
Fine-Tuning in DBI Inflationary Mechanism
We show a model-independent fine-tuning issue in the DBI inflationary mechanism. DBI inflation requires a warp factor h small enough to sufficiently slow down the inflaton. On the other hand, the Einstein equation in extra dimensions under the inflationary background deforms the warp space in the IR side. Generically these two locations coincide with each other, spoiling the DBI inflation. The ...
متن کاملTuning NOTCH
The emergence of multi-cellular organs and their organization into complex body plans is a major cornerstone concerning origin of life on Earth. This requires that the fundamental unit of life, namely the cell, must communicate, coordinate and organize. Cell communication mediated by signal transduction pathways is essential for the development and functioning of any organism. About 20 differen...
متن کاملFine-Tuning Tumor Endothelial Cells to Selectively Kill Cancer
Tumor endothelial cells regulate several aspects of tumor biology, from delivering oxygen and nutrients to shaping the immune response against a tumor and providing a barrier against tumor cell dissemination. Accordingly, targeting tumor endothelial cells represents an important modality in cancer therapy. Whereas initial anti-angiogenic treatments focused mainly on blocking the formation of ne...
متن کاملFine-tuning the angiogenic response to vascular endothelial growth factor.
Vascular endothelial growth factor (VEGF) is an important mediator of vascular development and postnatal angiogenesis.1,2 Homozygous deletion of VEGF gene leads to impaired vascular formation and early embryonic lethality.3 Interestingly, deletion of just one VEGF allele is sufficient to produce similar vascular abnormalities,3,4 suggesting that the strength and integrity of the VEGF signaling ...
متن کاملEndothelial-specific Notch blockade inhibits vascular function and tumor growth through an eNOS-dependent mechanism.
Notch signaling is important for tumor angiogenesis induced by vascular endothelial growth factor A. Blockade of the Notch ligand Dll4 inhibits tumor growth in a paradoxical way. Dll4 inhibition increases endothelial cell sprouting, but vessels show reduced perfusion. The reason for this lack of perfusion is not currently understood. Here we report that inhibition of Notch signaling in endothel...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Cell
سال: 2011
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2011.05.001